Developing Luminescent Lanthanide Coordination Polymers and Metal-Organic Frameworks for Bioimaging Applications

Aida Gonzalez, Xiu Mei-Chu, Jeffry Einkauf, Daniel Delill

Abstract


This study focuses on the solvothermal synthesis of two lanthanide-based coordination polymer/
metal-organic framework systems assembled from 1,3,5-benzenetricarboxylic acid (BTC) in
the nano-sized regime for use as bioimaging agents. These materials were synthesized using two
different lanthanide ions, a luminescent center (Eu, Tb) for optical imaging purposes and Gd,
whose magnetic properties are particularly beneficial in magnetic resonance imaging (MRI) as
a contrast agent. Together, these two features allow for multimodal imaging, useful in the study
and diagnosis of disease. Under identical reaction conditions, two different compounds were
formed upon changing the identity of the optically active lanthanide metal ion. Compound 1
([EuGd(BTC)2(H2O)12]) emerged as a one dimensional coordination polymer, increasing in size
with reaction time; while compound 2 ([TbGd(BTC)2(H2O)2]n•2DMF) emerged as a three dimensional
framework, decreasing in size with time. Both compounds displayed vibrant luminescence
upon UV excitation, indicating potential as bioimaging agents.


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